Cargando…

Identification and Characterization of B-Cell Epitopes in the DBL4ε Domain of VAR2CSA

Malaria during pregnancy in Plasmodium falciparum endemic regions is a major cause of mortality and severe morbidity. VAR2CSA is the parasite ligand responsible for sequestration of Plasmodium falciparum infected erythrocytes to the receptor chondroitin sulfate A (CSA) in the placenta and is the lea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ditlev, Sisse B., Nielsen, Morten A., Resende, Mafalda, Agerbæk, Mette Ø., Pinto, Vera V., Andersen, Pernille H., Magistrado, Pamela, Lusingu, John, Dahlbäck, Madeleine, Theander, Thor G., Salanti, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435390/ https://www.ncbi.nlm.nih.gov/pubmed/22970138 http://dx.doi.org/10.1371/journal.pone.0043663

Ejemplares similares

Structural Insight into Epitopes in the Pregnancy-Associated Malaria Protein VAR2CSA
por: Andersen, Pernille, et al.
Publicado: (2008)

Epitope Mapping and Topographic Analysis of VAR2CSA DBL3X Involved in P. falciparum Placental Sequestration
por: Dahlbäck, Madeleine, et al.
Publicado: (2006)

Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA
por: Resende, Mafalda, et al.
Publicado: (2008)

Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies
por: Salanti, Ali, et al.
Publicado: (2010)

Differential Induction of Functional IgG Using the Plasmodium falciparum Placental Malaria Vaccine Candidate VAR2CSA
por: Pinto, Vera V., et al.
Publicado: (2011)

A Novel Virus-Like Particle Based Vaccine Platform Displaying the Placental Malaria Antigen VAR2CSA
por: Thrane, Susan, et al.
Publicado: (2015)

The Chondroitin Sulfate A-binding Site of the VAR2CSA Protein Involves Multiple N-terminal Domains
por: Dahlbäck, Madeleine, et al.
Publicado: (2011)

Full-Length Recombinant Plasmodium falciparum VAR2CSA Binds Specifically to CSPG and Induces Potent Parasite Adhesion-Blocking Antibodies
por: Khunrae, Pongsak, et al.
Publicado: (2010)

Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA
por: Barfod, Lea, et al.
Publicado: (2007)

Utilizing Nanobody Technology to Target Non-Immunodominant Domains of VAR2CSA
por: Ditlev, Sisse B., et al.
Publicado: (2014)

Evidence for the Involvement of VAR2CSA in Pregnancy-associated Malaria
por: Salanti, Ali, et al.
Publicado: (2004)

Structure function analysis of P. falciparum VAR2CSA
por: Dahlbäck, Madeleine, et al.
Publicado: (2010)

Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions
por: Gangnard, Stéphane, et al.
Publicado: (2015)

The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine
por: Nielsen, Morten A., et al.
Publicado: (2015)

The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
por: Agerbæk, Mette Ø., et al.
Publicado: (2018)

Author Correction: The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
por: Agerbæk, Mette Ø., et al.
Publicado: (2022)

Detection of VAR2CSA-Captured Colorectal Cancer Cells from Blood Samples by Real-Time Reverse Transcription PCR
por: Bang-Christensen, Sara R., et al.
Publicado: (2021)

Plasmodium falciparum Variability and Immune Evasion Proceed from Antigenicity of Consensus Sequences from DBL6ε; Generalization to All DBL from VAR2CSA
por: Deloron, Philippe, et al.
Publicado: (2013)

Antibody responses to the full-length VAR2CSA and its DBL domains in Cameroonian children and teenagers
por: Fodjo, Barriere A. Y., et al.
Publicado: (2016)

Insight into Antigenic Diversity of VAR2CSA-DBL5ε Domain from Multiple Plasmodium falciparum Placental Isolates
por: Gnidehou, Sédami, et al.
Publicado: (2010)

Multiple var2csa-Type PfEMP1 Genes Located at Different Chromosomal Loci Occur in Many Plasmodium falciparum Isolates
por: Sander, Adam F., et al.
Publicado: (2009)

Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins
por: Avril, Marion, et al.
Publicado: (2011)

Infections with Plasmodium falciparum during pregnancy affect VAR2CSA DBL-5 domain-specific T cell cytokine responses
por: Gbédandé, Komi, et al.
Publicado: (2016)

Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
por: Wang, Kaituo, et al.
Publicado: (2021)

Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites
por: Dahlbäck, Madeleine, et al.
Publicado: (2007)

Towards the Rational Design of a Candidate Vaccine against Pregnancy Associated Malaria: Conserved Sequences of the DBL6ε Domain of VAR2CSA
por: Badaut, Cyril, et al.
Publicado: (2010)

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1
por: Ayres Pereira, Marina, et al.
Publicado: (2016)

Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein
por: Bang-Christensen, Sara R., et al.
Publicado: (2019)

Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
por: Fernandez, Pablo, et al.
Publicado: (2008)

Antibodies to full-length and the DBL5 domain of VAR2CSA in pregnant women after long-term implementation of intermittent preventive treatment in Etoudi, Cameroon
por: Djontu, Jean Claude, et al.
Publicado: (2020)

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A
por: Singh, Kavita, et al.
Publicado: (2008)

Structural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during Pregnancy
por: Khunrae, Pongsak, et al.
Publicado: (2009)

Strain-Transcendent Immune Response to Recombinant Var2CSA DBL5-ε Domain Block P. falciparum Adhesion to Placenta-Derived BeWo Cells under Flow Conditions
por: Fernandez, Pablo, et al.
Publicado: (2010)

The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs
por: Joergensen, Lars M, et al.
Publicado: (2010)

Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6∊-FCR3 of the Plasmodium falciparum VAR2CSA protein. Corrigendum
por: Vuchelen, Anneleen, et al.
Publicado: (2013)

Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development
por: Chêne, Arnaud, et al.
Publicado: (2018)

Polymorphic Molecular Signatures in Variable Regions of the Plasmodium falciparum var2csa DBL3x Domain Are Associated with Virulence in Placental Malaria
por: Talundzic, Eldin, et al.
Publicado: (2022)

An Upstream Open Reading Frame Controls Translation of var2csa, a Gene Implicated in Placental Malaria
por: Amulic, Borko, et al.
Publicado: (2009)

Sequence Polymorphism, Segmental Recombination and Toggling Amino Acid Residues within the DBL3X Domain of the VAR2CSA Placental Malaria Antigen
por: Talundzic, Eldin, et al.
Publicado: (2012)

Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain
por: Nunes-Silva, Sofia, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_e2rdi8s3t1b71mvg99p5i6gao8