A Novel In Vivo siRNA Delivery System Specifically Targeting Liver Cells for Protection of ConA-Induced Fulminant Hepatitis

BACKGROUND: Fulminant hepatitis progresses to acute liver failure (ALF) when the extent of hepatocyte death exceeds the liver's regenerative capacity. Although small interfering RNA (siRNA) appears promising in animal models of hepatitis, the approach is limited by drawbacks associated with sys...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Nan, Zhang, Xusheng, Zheng, Xiufen, Chen, Di, Siu, Kingsun, Wang, Hongmei, Ichim, Thomas E., Quan, Douglas, McAlister, Vivian, Chen, Guihua, Min, Wei-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435394/
https://www.ncbi.nlm.nih.gov/pubmed/22970170
http://dx.doi.org/10.1371/journal.pone.0044138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435394/
https://www.ncbi.nlm.nih.gov/pubmed/22970170
http://dx.doi.org/10.1371/journal.pone.0044138

Ejemplares similares