αA-Crystallin–Derived Mini-Chaperone Modulates Stability and Function of Cataract Causing αAG98R-Crystallin

BACKGROUND: A substitution mutation in human αA-crystallin (αAG98R) is associated with autosomal dominant cataract. The recombinant mutant αAG98R protein exhibits altered structure, substrate-dependent chaperone activity, impaired oligomer stability and aggregation on prolonged incubation at 37°C. O...

Descripción completa

Detalles Bibliográficos
Autores principales: Raju, Murugesan, Santhoshkumar, Puttur, Sharma, K. Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435407/
https://www.ncbi.nlm.nih.gov/pubmed/22970163
http://dx.doi.org/10.1371/journal.pone.0044077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435407/
https://www.ncbi.nlm.nih.gov/pubmed/22970163
http://dx.doi.org/10.1371/journal.pone.0044077

Ejemplares similares