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αA-Crystallin–Derived Mini-Chaperone Modulates Stability and Function of Cataract Causing αAG98R-Crystallin

BACKGROUND: A substitution mutation in human αA-crystallin (αAG98R) is associated with autosomal dominant cataract. The recombinant mutant αAG98R protein exhibits altered structure, substrate-dependent chaperone activity, impaired oligomer stability and aggregation on prolonged incubation at 37°C. O...

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Detalles Bibliográficos
Autores principales:	Raju, Murugesan, Santhoshkumar, Puttur, Sharma, K. Krishna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435407/ https://www.ncbi.nlm.nih.gov/pubmed/22970163 http://dx.doi.org/10.1371/journal.pone.0044077

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