Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency

NOTCH1 pathway activation contributes to the pathogenesis of over 60% of T-cell acute lymphoblastic leukemia (T-ALL). While Notch is thought to exert the majority of its effects through transcriptional activation of Myc, it also likely has independent roles in T-ALL malignancy. Here, we utilized a z...

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Detalles Bibliográficos
Autores principales: Blackburn, Jessica S., Liu, Sali, Raiser, David M., Martinez, Sarah A., Feng, Hui, Meeker, Nathan D., Gentry, Jeffery, Neuberg, Donna, Look, A. Thomas, Ramaswamy, Sridhar, Bernards, Andre, Trede, Nikolaus S., Langenau, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435461/
https://www.ncbi.nlm.nih.gov/pubmed/22538478
http://dx.doi.org/10.1038/leu.2012.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435461/
https://www.ncbi.nlm.nih.gov/pubmed/22538478
http://dx.doi.org/10.1038/leu.2012.116

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