Side-chain rotamer changes upon ligand binding: common, crucial, correlate with entropy and rearrange hydrogen bonding

Motivation: Protein movements form a continuum from large domain rearrangements (including folding and restructuring) to side-chain rotamer changes and small rearrangements. Understanding side-chain flexibility upon binding is important to understand molecular recognition events and predict ligand b...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaudreault, Francis, Chartier, Matthieu, Najmanovich, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436822/
https://www.ncbi.nlm.nih.gov/pubmed/22962462
http://dx.doi.org/10.1093/bioinformatics/bts395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436822/
https://www.ncbi.nlm.nih.gov/pubmed/22962462
http://dx.doi.org/10.1093/bioinformatics/bts395

Ejemplares similares