Nonlinear dimension reduction with Wright–Fisher kernel for genotype aggregation and association mapping

Motivation: Association tests based on next-generation sequencing data are often under-powered due to the presence of rare variants and large amount of neutral or protective variants. A successful strategy is to aggregate genetic information within meaningful single-nucleotide polymorphism (SNP) set...

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Detalles Bibliográficos
Autores principales: Zhu, Hongjie, Li, Lexin, Zhou, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436833/
https://www.ncbi.nlm.nih.gov/pubmed/22962455
http://dx.doi.org/10.1093/bioinformatics/bts406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436833/
https://www.ncbi.nlm.nih.gov/pubmed/22962455
http://dx.doi.org/10.1093/bioinformatics/bts406

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