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Nonlinear dimension reduction with Wright–Fisher kernel for genotype aggregation and association mapping
Motivation: Association tests based on next-generation sequencing data are often under-powered due to the presence of rare variants and large amount of neutral or protective variants. A successful strategy is to aggregate genetic information within meaningful single-nucleotide polymorphism (SNP) set...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436833/ https://www.ncbi.nlm.nih.gov/pubmed/22962455 http://dx.doi.org/10.1093/bioinformatics/bts406 |