Suppression of IFN-Induced Transcription Underlies IFN Defects Generated by Activated Ras/MEK in Human Cancer Cells

Certain oncolytic viruses exploit activated Ras signaling in order to replicate in cancer cells. Constitutive activation of the Ras/MEK pathway is known to suppress the effectiveness of the interferon (IFN) antiviral response, which may contribute to Ras-dependent viral oncolysis. Here, we identifie...

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Detalles Bibliográficos
Autores principales: Christian, Sherri L., Zu, Dong, Licursi, Maria, Komatsu, Yumiko, Pongnopparat, Theerawat, Codner, Dianne A., Hirasawa, Kensuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436881/
https://www.ncbi.nlm.nih.gov/pubmed/22970192
http://dx.doi.org/10.1371/journal.pone.0044267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436881/
https://www.ncbi.nlm.nih.gov/pubmed/22970192
http://dx.doi.org/10.1371/journal.pone.0044267

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