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Suppression of IFN-Induced Transcription Underlies IFN Defects Generated by Activated Ras/MEK in Human Cancer Cells

Certain oncolytic viruses exploit activated Ras signaling in order to replicate in cancer cells. Constitutive activation of the Ras/MEK pathway is known to suppress the effectiveness of the interferon (IFN) antiviral response, which may contribute to Ras-dependent viral oncolysis. Here, we identifie...

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Detalles Bibliográficos
Autores principales:	Christian, Sherri L., Zu, Dong, Licursi, Maria, Komatsu, Yumiko, Pongnopparat, Theerawat, Codner, Dianne A., Hirasawa, Kensuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436881/ https://www.ncbi.nlm.nih.gov/pubmed/22970192 http://dx.doi.org/10.1371/journal.pone.0044267

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