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Novel African Trypanocidal Agents: Membrane Rigidifying Peptides
The bloodstream developmental forms of pathogenic African trypanosomes are uniquely susceptible to killing by small hydrophobic peptides. Trypanocidal activity is conferred by peptide hydrophobicity and charge distribution and results from increased rigidity of the plasma membrane. Structural analys...
Autores principales: | Harrington, John M., Scelsi, Chris, Hartel, Andreas, Jones, Nicola G., Engstler, Markus, Capewell, Paul, MacLeod, Annette, Hajduk, Stephen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436892/ https://www.ncbi.nlm.nih.gov/pubmed/22970207 http://dx.doi.org/10.1371/journal.pone.0044384 |
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