Human Cytomegalovirus Induces TLR4 Signaling Components in Monocytes Altering TIRAP, TRAM and Downstream Interferon-Beta and TNF-Alpha Expression

Using TLR pathways, primary human cytomegalovirus (HCMV) induces innate responses including the production of inflammatory cytokines. Mounting evidence suggests that LPS recognition by TLR4/MD2/CD14 results in differential utilization of TIRAP-TRAF6 and TRAM-TRIF signaling, thereby leading to transc...

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Detalles Bibliográficos
Autores principales: Yew, Kok-Hooi, Carpenter, Cory, Duncan, R. Scott, Harrison, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436894/
https://www.ncbi.nlm.nih.gov/pubmed/22970235
http://dx.doi.org/10.1371/journal.pone.0044500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436894/
https://www.ncbi.nlm.nih.gov/pubmed/22970235
http://dx.doi.org/10.1371/journal.pone.0044500

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