Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex

The loading of antigenic peptides onto major histocompatibility complex class I (MHC I) molecules is an essential step in the adaptive immune response against virally or malignantly transformed cells. The ER-resident peptide-loading complex (PLC) consists of the transporter associated with antigen p...

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Detalles Bibliográficos
Autores principales: Hulpke, Sabine, Tomioka, Maiko, Kremmer, Elisabeth, Ueda, Kazumitsu, Abele, Rupert, Tampé, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437018/
https://www.ncbi.nlm.nih.gov/pubmed/22638925
http://dx.doi.org/10.1007/s00018-012-1005-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437018/
https://www.ncbi.nlm.nih.gov/pubmed/22638925
http://dx.doi.org/10.1007/s00018-012-1005-6

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