Cargando…

Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex

The loading of antigenic peptides onto major histocompatibility complex class I (MHC I) molecules is an essential step in the adaptive immune response against virally or malignantly transformed cells. The ER-resident peptide-loading complex (PLC) consists of the transporter associated with antigen p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hulpke, Sabine, Tomioka, Maiko, Kremmer, Elisabeth, Ueda, Kazumitsu, Abele, Rupert, Tampé, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SP Birkhäuser Verlag Basel 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437018/ https://www.ncbi.nlm.nih.gov/pubmed/22638925 http://dx.doi.org/10.1007/s00018-012-1005-6

Ejemplares similares

Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch
por: Blees, Andreas, et al.
Publicado: (2015)

Structure and Dynamics of Antigenic Peptides in Complex with TAP
por: Lehnert, Elisa, et al.
Publicado: (2017)

Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter
por: Grossmann, Nina, et al.
Publicado: (2014)

Proofreading of Peptide—MHC Complexes through Dynamic Multivalent Interactions
por: Thomas, Christoph, et al.
Publicado: (2017)

Molecular mechanism of peptide editing in the tapasin–MHC I complex
por: Fisette, Olivier, et al.
Publicado: (2016)

MHC class I molecules form ternary complexes with calnexin and TAP and undergo peptide-regulated interaction with TAP via their extracellular domains
Publicado: (1996)

Semisynthetic Viral Inhibitor for Light Control of the MHC I Peptide Loading Complex
por: Winter, Christian, et al.
Publicado: (2022)

A dual inhibition mechanism of herpesviral ICP47 arresting a conformationally thermostable TAP complex
por: Herbring, Valentina, et al.
Publicado: (2016)

Molecular basis of MHC I quality control in the peptide loading complex
por: Domnick, Alexander, et al.
Publicado: (2022)

Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking
por: Brunnberg, Jamina, et al.
Publicado: (2021)

Moving the Cellular Peptidome by Transporters
por: Abele, Rupert, et al.
Publicado: (2018)

Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity
por: Müller, Ines Katharina, et al.
Publicado: (2022)

Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells
por: Koller, Nicole, et al.
Publicado: (2022)

Dynamic interactome of the MHC I peptide loading complex in human dendritic cells
por: Barends, Martina, et al.
Publicado: (2023)

Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling
por: Campi, Gabriele, et al.
Publicado: (2005)

The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I
por: Sagert, Lina, et al.
Publicado: (2023)

Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex
por: Sethumadhavan, Sunesh, et al.
Publicado: (2022)

Interferon Alpha Signalling and Its Relevance for the Upregulatory Effect of Transporter Proteins Associated with Antigen Processing (TAP) in Patients with Malignant Melanoma
por: Heise, Ruth, et al.
Publicado: (2016)

The Active Site of ICP47, a Herpes Simplex Virus–encoded Inhibitor of the Major Histocompatibility Complex (MHC)-encoded Peptide Transporter Associated with Antigen Processing (TAP), Maps to the NH(2)-terminal 35 Residues
por: Galocha, Begoña, et al.
Publicado: (1997)

Loss of antigen-presenting molecules (MHC class I and TAP-1) in lung cancer.
por: Korkolopoulou, P., et al.
Publicado: (1996)

TAP, a novel T cell-activating protein involved in the stimulation of MHC-restricted T lymphocytes
Publicado: (1986)

MHCBN 4.0: A database of MHC/TAP binding peptides and T-cell epitopes
por: Lata, Sneh, et al.
Publicado: (2009)

High-Resolution Genotyping of Expressed Equine MHC Reveals a Highly Complex MHC Structure
por: Vasoya, Deepali, et al.
Publicado: (2023)

Major Histocompatibility Complex (MHC) Markers in Conservation Biology
por: Ujvari, Beata, et al.
Publicado: (2011)

PW03-010 - MHC complexity in Behçet's disease
por: Ombrello, MJ, et al.
Publicado: (2013)

The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review
por: Mokhtari, Ryan, et al.
Publicado: (2016)

Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids
por: Plasil, Martin, et al.
Publicado: (2022)

Peptide translocation by the lysosomal ABC transporter TAPL is regulated by coupling efficiency and activation energy
por: Bock, Christoph, et al.
Publicado: (2019)

Tapping into Permutation Symmetry for Improved Detection of k-Symmetric Extensions
por: Li, Youning, et al.
Publicado: (2023)

Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection
Publicado: (1992)

T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen
Publicado: (1993)

The Specificity and Polymorphism of the MHC Class I Prevents the Global Adaptation of HIV-1 to the Monomorphic Proteasome and TAP
por: Schmid, Boris, et al.
Publicado: (2008)

Differences in MHC and TAP-1 expression in cervical cancer lymph node metastases as compared with the primary tumours.
por: Cromme, F. V., et al.
Publicado: (1994)

Is acting on delusions autonomous?
por: Schlimme, Jann E
Publicado: (2013)

Understanding TR Binding to pMHC Complexes: How Does a TR Scan Many pMHC Complexes yet Preferentially Bind to One
por: Khan, Javed Mohammed, et al.
Publicado: (2011)

The V beta complementarity determining region 1 of a major histocompatibility complex (MHC) class I-restricted T cell receptor is involved in the recognition of peptide/MHC I and superantigen/MHC II complex
Publicado: (1994)

Inactivation of Enveloped Viruses by a Silver-Thiosulfate Complex
por: Oka, Hiroaki, et al.
Publicado: (1994)

Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination
por: Cho, Kyung-Jin, et al.
Publicado: (2013)

Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish
por: Yamaguchi, Takuya, et al.
Publicado: (2019)

Information-Driven Docking for TCR-pMHC Complex Prediction
por: Peacock, Thomas, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hgrdbqvhd8gpurgl8f3fmg1e40