Selective Deactivation of Serum IgG: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions

Serum IgG is a potent inhibitor of monoclonal antibody (mAb) binding to the cell-surface Fcγ receptors (FcγRs), which mediate cytotoxic and phagocytic effector functions. Here, we show that this competition can be eliminated, selectively, by the introduction to serum of (i) an enzyme that displaces...

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Detalles Bibliográficos
Autores principales: Baruah, Kavitha, Bowden, Thomas A., Krishna, Benjamin A., Dwek, Raymond A., Crispin, Max, Scanlan, Christopher N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437440/
https://www.ncbi.nlm.nih.gov/pubmed/22484364
http://dx.doi.org/10.1016/j.jmb.2012.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437440/
https://www.ncbi.nlm.nih.gov/pubmed/22484364
http://dx.doi.org/10.1016/j.jmb.2012.04.002

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