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N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis
[Image: see text] Base-promoted 5-exo-dig cyclizations of aza-propargylglycinamides provided N-amino-imidazolin-2-one peptide mimics, which exhibited turn geometry in X-ray crystallographic and NMR spectroscopic analyses. Sonogashira coupling prior to cyclization afforded N-amino-imidazolin-2-ones w...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437692/ https://www.ncbi.nlm.nih.gov/pubmed/22892053 http://dx.doi.org/10.1021/ol302021n |
| _version_ | 1782242816992215040 |
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| author | Proulx, Caroline Lubell, William D. |
| author_facet | Proulx, Caroline Lubell, William D. |
| author_sort | Proulx, Caroline |
| collection | PubMed |
| description | [Image: see text] Base-promoted 5-exo-dig cyclizations of aza-propargylglycinamides provided N-amino-imidazolin-2-one peptide mimics, which exhibited turn geometry in X-ray crystallographic and NMR spectroscopic analyses. Sonogashira coupling prior to cyclization afforded N-amino-imidazolin-2-ones with diverse 4-position aromatic substituents with potential to serve as Phe and Trp mimics. |
| format | Online Article Text |
| id | pubmed-3437692 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-34376922012-09-10 N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis Proulx, Caroline Lubell, William D. Org Lett [Image: see text] Base-promoted 5-exo-dig cyclizations of aza-propargylglycinamides provided N-amino-imidazolin-2-one peptide mimics, which exhibited turn geometry in X-ray crystallographic and NMR spectroscopic analyses. Sonogashira coupling prior to cyclization afforded N-amino-imidazolin-2-ones with diverse 4-position aromatic substituents with potential to serve as Phe and Trp mimics. American Chemical Society 2012-08-14 2012-09-07 /pmc/articles/PMC3437692/ /pubmed/22892053 http://dx.doi.org/10.1021/ol302021n Text en Copyright © 2012 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org. |
| spellingShingle | Proulx, Caroline Lubell, William D. N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis |
| title | N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis |
| title_full | N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis |
| title_fullStr | N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis |
| title_full_unstemmed | N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis |
| title_short | N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis |
| title_sort | n-amino-imidazolin-2-one peptide mimic synthesis and conformational analysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437692/ https://www.ncbi.nlm.nih.gov/pubmed/22892053 http://dx.doi.org/10.1021/ol302021n |
| work_keys_str_mv | AT proulxcaroline naminoimidazolin2onepeptidemimicsynthesisandconformationalanalysis AT lubellwilliamd naminoimidazolin2onepeptidemimicsynthesisandconformationalanalysis |