In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway

BACKGROUND: Deoxyhypusine synthase (DHS) catalyzes the first step in hypusine biosynthesis of eukaryotic initiation factor 5A (eIF-5A) in Plasmodium falciparum. Target evaluation of parasitic DHS has recently been performed with CNI-1493, a novel selective pro-inflammatory cytokine inhibitor used in...

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Detalles Bibliográficos
Autores principales: Schwentke, Andreas, Krepstakies, Marcel, Mueller, Ann-Kristin, Hammerschmidt-Kamper, Christiane, Motaal, Basma A, Bernhard, Tina, Hauber, Joachim, Kaiser, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438091/
https://www.ncbi.nlm.nih.gov/pubmed/22694849
http://dx.doi.org/10.1186/1471-2180-12-107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438091/
https://www.ncbi.nlm.nih.gov/pubmed/22694849
http://dx.doi.org/10.1186/1471-2180-12-107

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