CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

BACKGROUND: The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only approved drug effective against the persistent liver stage of the hypnozoite forming strains Plasmodium vivax and Plasmodium ovale as well as Stage V gametocytes of Plasmodium falciparum. To date, several groups have i...

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Detalles Bibliográficos
Autores principales: Pybus, Brandon S, Sousa, Jason C, Jin, Xiannu, Ferguson, James A, Christian, Robert E, Barnhart, Rebecca, Vuong, Chau, Sciotti, Richard J, Reichard, Gregory A, Kozar, Michael P, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438098/
https://www.ncbi.nlm.nih.gov/pubmed/22856549
http://dx.doi.org/10.1186/1475-2875-11-259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438098/
https://www.ncbi.nlm.nih.gov/pubmed/22856549
http://dx.doi.org/10.1186/1475-2875-11-259

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