Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines

BACKGROUND: Canine hemangiosarcoma (HSA) is a malignant tumor with poor long-term prognosis due to development of metastasis despite aggressive treatment. The phosphatidyl-inositol-3 kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is involved in its endothelial pathologies; however,...

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Detalles Bibliográficos
Autores principales: Murai, Atsuko, Asa, Samah Abou, Kodama, Atsushi, Hirata, Akihiro, Yanai, Tokuma, Sakai, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438112/
https://www.ncbi.nlm.nih.gov/pubmed/22839755
http://dx.doi.org/10.1186/1746-6148-8-128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438112/
https://www.ncbi.nlm.nih.gov/pubmed/22839755
http://dx.doi.org/10.1186/1746-6148-8-128

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