Identification of Elongation Factor G as the Conserved Cellular Target of Argyrin B

Argyrins, produced by myxobacteria and actinomycetes, are cyclic octapeptides with antibacterial and antitumor activity. Here, we identify elongation factor G (EF-G) as the cellular target of argyrin B in bacteria, via resistant mutant selection and whole genome sequencing, biophysical binding studi...

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Detalles Bibliográficos
Autores principales: Nyfeler, Beat, Hoepfner, Dominic, Palestrant, Deborah, Kirby, Christina A., Whitehead, Lewis, Yu, Robert, Deng, Gejing, Caughlan, Ruth E., Woods, Angela L., Jones, Adriana K., Barnes, S. Whitney, Walker, John R., Gaulis, Swann, Hauy, Ervan, Brachmann, Saskia M., Krastel, Philipp, Studer, Christian, Riedl, Ralph, Estoppey, David, Aust, Thomas, Movva, N. Rao, Wang, Zuncai, Salcius, Michael, Michaud, Gregory A., McAllister, Gregory, Murphy, Leon O., Tallarico, John A., Wilson, Christopher J., Dean, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438169/
https://www.ncbi.nlm.nih.gov/pubmed/22970117
http://dx.doi.org/10.1371/journal.pone.0042657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438169/
https://www.ncbi.nlm.nih.gov/pubmed/22970117
http://dx.doi.org/10.1371/journal.pone.0042657

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