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Endogenous antigen tunes the responsiveness of naive B cells but not T cells
In humans up to 75% of newly generated B cells and about 30% of mature B cells exhibit some degree of autoreactivity(1). Yet, how B cells establish and maintain tolerance in the face of autoantigen exposure during and after development is not certain. Studies of model BCR transgenic systems have hig...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438375/ https://www.ncbi.nlm.nih.gov/pubmed/22902503 http://dx.doi.org/10.1038/nature11311 |