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Endogenous antigen tunes the responsiveness of naive B cells but not T cells

In humans up to 75% of newly generated B cells and about 30% of mature B cells exhibit some degree of autoreactivity(1). Yet, how B cells establish and maintain tolerance in the face of autoantigen exposure during and after development is not certain. Studies of model BCR transgenic systems have hig...

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Detalles Bibliográficos
Autores principales: Zikherman, Julie, Parameswaran, Ramya, Weiss, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438375/
https://www.ncbi.nlm.nih.gov/pubmed/22902503
http://dx.doi.org/10.1038/nature11311