Cargando…
Endogenous antigen tunes the responsiveness of naive B cells but not T cells
In humans up to 75% of newly generated B cells and about 30% of mature B cells exhibit some degree of autoreactivity(1). Yet, how B cells establish and maintain tolerance in the face of autoantigen exposure during and after development is not certain. Studies of model BCR transgenic systems have hig...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438375/ https://www.ncbi.nlm.nih.gov/pubmed/22902503 http://dx.doi.org/10.1038/nature11311 |