Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

The lissencephaly protein Lis1 has been reported to regulate the mechanical behavior of cytoplasmic dynein, the primary minus-end-directed microtubule motor. However, the regulatory mechanism remains poorly understood. Here, we address this issue using purified proteins from Saccharomyces cerevisiae...

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Detalles Bibliográficos
Autores principales: Huang, Julie, Roberts, Anthony J., Leschziner, Andres E., Reck-Peterson, Samara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438448/
https://www.ncbi.nlm.nih.gov/pubmed/22939623
http://dx.doi.org/10.1016/j.cell.2012.07.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438448/
https://www.ncbi.nlm.nih.gov/pubmed/22939623
http://dx.doi.org/10.1016/j.cell.2012.07.022

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