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β-hairpin forms by rolling up from C-terminal: Topological guidance of early folding dynamics

That protein folding is a non-random, guided process has been known even prior to Levinthal's paradox; yet, guided searches, attendant mechanisms and their relation to primary sequence remain obscure. Using extensive molecular dynamics simulations of a β-hairpin with key sequence features simil...

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Detalles Bibliográficos
Autores principales: Enemark, Søren, Kurniawan, Nicholas A., Rajagopalan, Raj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438464/
https://www.ncbi.nlm.nih.gov/pubmed/22970341
http://dx.doi.org/10.1038/srep00649

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