Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a master regulator of glycolysis by its ability to synthesize fructose-2,6-bisphosphate, a potent allosteric activator of 6-phosphofructo-1-kinase. Being a substrate of the E3 ubiquitin ligase anaphase-promoting complex-Cdh1 (APC(Cdh...

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Detalles Bibliográficos
Autores principales: Rodriguez-Rodriguez, P, Fernandez, E, Almeida, A, Bolaños, J P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438489/
https://www.ncbi.nlm.nih.gov/pubmed/22421967
http://dx.doi.org/10.1038/cdd.2012.33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438489/
https://www.ncbi.nlm.nih.gov/pubmed/22421967
http://dx.doi.org/10.1038/cdd.2012.33

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