Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

Mutations in the renal tumour suppressor protein, folliculin, lead to proliferative skin lesions, lung complications and renal cell carcinoma. Folliculin has been reported to interact with AMP-activated kinase, a key component of the mammalian target of rapamycin pathway. Most cancer-causing mutatio...

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Detalles Bibliográficos
Autores principales: Nookala, Ravi K., Langemeyer, Lars, Pacitto, Angela, Ochoa-Montaño, Bernardo, Donaldson, Jane C., Blaszczyk, Beata K., Chirgadze, Dimitri Y., Barr, Francis A., Bazan, J. Fernando, Blundell, Tom L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438538/
https://www.ncbi.nlm.nih.gov/pubmed/22977732
http://dx.doi.org/10.1098/rsob.120071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438538/
https://www.ncbi.nlm.nih.gov/pubmed/22977732
http://dx.doi.org/10.1098/rsob.120071

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