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Genome-wide Epigenetic Data Facilitate Understanding of Disease Susceptibility Association Studies

Complex traits such as susceptibility to diseases are determined in part by variants at multiple genetic loci. Genome-wide association studies can identify these loci, but most phenotype-associated variants lie distal to protein-coding regions and are likely involved in regulating gene expression. U...

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Detalles Bibliográficos
Autor principal: Hardison, Ross C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438926/
https://www.ncbi.nlm.nih.gov/pubmed/22952232
http://dx.doi.org/10.1074/jbc.R112.352427