Structure and Mechanism of Human UDP-xylose Synthase: EVIDENCE FOR A PROMOTING ROLE OF SUGAR RING DISTORTION IN A THREE-STEP CATALYTIC CONVERSION OF UDP-GLUCURONIC ACID

UDP-xylose synthase (UXS) catalyzes decarboxylation of UDP-d-glucuronic acid to UDP-xylose. In mammals, UDP-xylose serves to initiate glycosaminoglycan synthesis on the protein core of extracellular matrix proteoglycans. Lack of UXS activity leads to a defective extracellular matrix, resulting in st...

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Detalles Bibliográficos
Autores principales: Eixelsberger, Thomas, Sykora, Sabine, Egger, Sigrid, Brunsteiner, Michael, Kavanagh, Kathryn L., Oppermann, Udo, Brecker, Lothar, Nidetzky, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438964/
https://www.ncbi.nlm.nih.gov/pubmed/22810237
http://dx.doi.org/10.1074/jbc.M112.386706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438964/
https://www.ncbi.nlm.nih.gov/pubmed/22810237
http://dx.doi.org/10.1074/jbc.M112.386706

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