Apolipoprotein E4 Is Deficient in Inducing Macrophage ABCA1 Expression and Stimulating the Sp1 Signaling Pathway

ATP binding cassette A1 (ABCA1) is a membrane protein that promotes cellular cholesterol efflux. Using RAW 264.7 macrophages, we studied the relative effects of apolipoprotein (apo) E3 and apoE4 on ABCA1 and on the signaling pathway that regulates its expression. Both lipid-associated and lipid-free...

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Detalles Bibliográficos
Autores principales: Okoro, Emmanuel Ugochukwu, Zhao, Yanfeng, Guo, ZhongMao, Zhou, Lichun, Lin, Xinghua, Yang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439389/
https://www.ncbi.nlm.nih.gov/pubmed/22984509
http://dx.doi.org/10.1371/journal.pone.0044430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439389/
https://www.ncbi.nlm.nih.gov/pubmed/22984509
http://dx.doi.org/10.1371/journal.pone.0044430

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