Site Specific Cleavage Mediated by MMPs Regulates Function of Agrin

BACKGROUND: Agrin is the key inducer of postsynaptic differentiations at the neuromuscular junction. The multidomain heparan sulfate proteoglycan is mediating via its N-terminal segment the interaction with laminin, whereas the C-terminal portion is responsible for Dystroglycan binding and clusterin...

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Detalles Bibliográficos
Autores principales: Patel, Trushar R., Butler, Georgina, McFarlane, Ainsley, Xie, Irene, Overall, Christopher M., Stetefeld, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439447/
https://www.ncbi.nlm.nih.gov/pubmed/22984437
http://dx.doi.org/10.1371/journal.pone.0043669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439447/
https://www.ncbi.nlm.nih.gov/pubmed/22984437
http://dx.doi.org/10.1371/journal.pone.0043669

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