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Site Specific Cleavage Mediated by MMPs Regulates Function of Agrin

BACKGROUND: Agrin is the key inducer of postsynaptic differentiations at the neuromuscular junction. The multidomain heparan sulfate proteoglycan is mediating via its N-terminal segment the interaction with laminin, whereas the C-terminal portion is responsible for Dystroglycan binding and clusterin...

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Detalles Bibliográficos
Autores principales:	Patel, Trushar R., Butler, Georgina, McFarlane, Ainsley, Xie, Irene, Overall, Christopher M., Stetefeld, Jörg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439447/ https://www.ncbi.nlm.nih.gov/pubmed/22984437 http://dx.doi.org/10.1371/journal.pone.0043669

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