Ablation of Dihydroceramide Desaturase Confers Resistance to Etoposide-Induced Apoptosis In Vitro

Sphingolipid biosynthesis is potently upregulated by factors associated with cellular stress, including numerous chemotherapeutics, inflammatory cytokines, and glucocorticoids. Dihydroceramide desaturase 1 (Des1), the third enzyme in the highly conserved pathway driving sphingolipid biosynthesis, in...

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Detalles Bibliográficos
Autores principales: Siddique, Monowarul M., Bikman, Benjamin T., Wang, Liping, Ying, Li, Reinhardt, Erin, Shui, Guanghou, Wenk, Markus R., Summers, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439484/
https://www.ncbi.nlm.nih.gov/pubmed/22984457
http://dx.doi.org/10.1371/journal.pone.0044042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439484/
https://www.ncbi.nlm.nih.gov/pubmed/22984457
http://dx.doi.org/10.1371/journal.pone.0044042

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