High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity

The G-quadruplex architecture is a peculiar structure adopted by guanine-rich oligonucleotidic sequences, and, in particular, by several aptamers, including the thrombin-binding aptamer (TBA) that has the highest inhibitory activity against human α-thrombin. A crucial role in determining structure,...

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Detalles Bibliográficos
Autores principales: Russo Krauss, Irene, Merlino, Antonello, Randazzo, Antonio, Novellino, Ettore, Mazzarella, Lelio, Sica, Filomena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439905/
https://www.ncbi.nlm.nih.gov/pubmed/22669903
http://dx.doi.org/10.1093/nar/gks512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439905/
https://www.ncbi.nlm.nih.gov/pubmed/22669903
http://dx.doi.org/10.1093/nar/gks512

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