Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans

Mitochondria lack the ability to repair certain helix-distorting lesions that are induced at high levels in mitochondrial DNA (mtDNA) by important environmental genotoxins and endogenous metabolites. These lesions are irreparable and persistent in the short term, but their long-term fate is unknown....

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Detalles Bibliográficos
Autores principales: Bess, Amanda S., Crocker, Tracey L., Ryde, Ian T., Meyer, Joel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439916/
https://www.ncbi.nlm.nih.gov/pubmed/22718972
http://dx.doi.org/10.1093/nar/gks532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439916/
https://www.ncbi.nlm.nih.gov/pubmed/22718972
http://dx.doi.org/10.1093/nar/gks532

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