Cargando…

Cross talk between the nuclease and helicase activities of Dna2: role of an essential iron–sulfur cluster domain

Dna2 nuclease/helicase is a multitasking protein involved in DNA replication and recombinational repair, and it is important for preservation of genomic stability. Yeast Dna2 protein contains a conserved putative Fe–S (iron–sulfur) cluster signature motif spanning the nuclease active site. We show t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pokharel, Subhash, Campbell, Judith L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439918/ https://www.ncbi.nlm.nih.gov/pubmed/22684504 http://dx.doi.org/10.1093/nar/gks534

Ejemplares similares

Mus81 nuclease and Sgs1 helicase are essential for meiotic recombination in a protist lacking a synaptonemal complex
por: Lukaszewicz, Agnieszka, et al.
Publicado: (2013)

Disease-associated DNA2 nuclease–helicase protects cells from lethal chromosome under-replication
por: Falquet, Benoît, et al.
Publicado: (2020)

Recombination hotspots attenuate the coupled ATPase and translocase activities of an AddAB-type helicase–nuclease
por: Gilhooly, Neville S., et al.
Publicado: (2014)

The RecB helicase-nuclease tether mediates Chi hotspot control of RecBCD enzyme
por: Amundsen, Susan K, et al.
Publicado: (2019)

Homologous recombination mediated by the mycobacterial AdnAB helicase without end resection by the AdnAB nucleases
por: Gupta, Richa, et al.
Publicado: (2017)

CRISPR–Cas adaptation in Escherichia coli requires RecBCD helicase but not nuclease activity, is independent of homologous recombination, and is antagonized by 5′ ssDNA exonucleases
por: Radovčić, Marin, et al.
Publicado: (2018)

Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability
por: Díaz de la Loza, María del Carmen, et al.
Publicado: (2011)

Structural evidence for an essential Fe–S cluster in the catalytic core domain of DNA polymerase ϵ
por: ter Beek, Josy, et al.
Publicado: (2019)

The nuclease FAN1 is involved in DNA crosslink repair in Arabidopsis thaliana independently of the nuclease MUS81
por: Herrmann, Natalie J., et al.
Publicado: (2015)

SirA inhibits the essential DnaA:DnaD interaction to block helicase recruitment during Bacillus subtilis sporulation
por: Winterhalter, Charles, et al.
Publicado: (2022)

The structure and function of an RNA polymerase interaction domain in the PcrA/UvrD helicase
por: Sanders, Kelly, et al.
Publicado: (2017)

The signature motif of the Saccharomyces cerevisiae Pif1 DNA helicase is essential in vivo for mitochondrial and nuclear functions and in vitro for ATPase activity
por: Geronimo, Carly L, et al.
Publicado: (2018)

Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association
por: Sarangi, Prabha, et al.
Publicado: (2014)

The role of SLX4 and its associated nucleases in DNA interstrand crosslink repair
por: Hoogenboom, Wouter S, et al.
Publicado: (2019)

Recognition and processing of branched DNA substrates by Slx1–Slx4 nuclease
por: Gaur, Vineet, et al.
Publicado: (2019)

The helicase-binding domain of Escherichia coli DnaG primase interacts with the highly conserved C-terminal region of single-stranded DNA-binding protein
por: Naue, Natalie, et al.
Publicado: (2013)

Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination
por: Gilhooly, Neville S., et al.
Publicado: (2016)

Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE
por: Sen, Doyel, et al.
Publicado: (2016)

WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase
por: Chakraborty, Prasun, et al.
Publicado: (2010)

Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2
por: Tsabar, Michael, et al.
Publicado: (2015)

The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication
por: Levikova, Maryna, et al.
Publicado: (2015)

DnaB helicase dynamics in bacterial DNA replication resolved by single-molecule studies
por: Spinks, Richard R, et al.
Publicado: (2021)

Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains
por: Gyimesi, Máté, et al.
Publicado: (2012)

RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription
por: Kanagaraj, Radhakrishnan, et al.
Publicado: (2010)

The helicase Pif1 functions in the template switching pathway of DNA damage bypass
por: García-Rodríguez, Néstor, et al.
Publicado: (2018)

Molecular characteristics of reiterative DNA unwinding by the Caenorhabditis elegans RecQ helicase
por: Choi, Seoyun, et al.
Publicado: (2019)

Processing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo
por: Kahli, Malik, et al.
Publicado: (2019)

Identification of the Xenopus DNA2 protein as a major nuclease for the 5′→3′ strand-specific processing of DNA ends
por: Liao, Shuren, et al.
Publicado: (2008)

An aromatic-rich loop couples DNA binding and ATP hydrolysis in the PriA DNA helicase
por: Windgassen, Tricia A., et al.
Publicado: (2016)

G-quadruplex recognition and remodeling by the FANCJ helicase
por: Wu, Colin G., et al.
Publicado: (2016)

The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair
por: Liao, Shuren, et al.
Publicado: (2016)

The 2B subdomain of Rep helicase links translocation along DNA with protein displacement
por: Brüning, Jan-Gert, et al.
Publicado: (2018)

Mycobacterial helicase Lhr abets resistance to DNA crosslinking agents mitomycin C and cisplatin
por: Warren, Garrett M, et al.
Publicado: (2023)

FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability
por: Liu, Wenpeng, et al.
Publicado: (2023)

The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction
por: Zhai, Binyuan, et al.
Publicado: (2018)

Structural parameters of palindromic repeats determine the specificity of nuclease attack of secondary structures
por: Ait Saada, Anissia, et al.
Publicado: (2021)

Overcoming natural replication barriers: differential helicase requirements
por: Anand, Ranjith P., et al.
Publicado: (2012)

A DNA break inducer activates the anticodon nuclease RloC and the adaptive immunity in Acinetobacter baylyi ADP1
por: Klaiman, Daniel, et al.
Publicado: (2014)

Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences
por: Kappeler, Michael, et al.
Publicado: (2008)

The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis
por: Jemt, Elisabeth, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ikhtck94oighcora41me9gi1ps