An ectopic CTCF-dependent transcriptional insulator influences the choice of Vβ gene segments for VDJ recombination at TCRβ locus

Insulators regulate transcription as they modulate the interactions between enhancers and promoters by organizing the chromatin into distinct domains. To gain better understanding of the nature of chromatin domains defined by insulators, we analyzed the ability of an insulator to interfere in VDJ re...

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Detalles Bibliográficos
Autores principales: Shrimali, Sweety, Srivastava, Surabhi, Varma, Garima, Grinberg, Alex, Pfeifer, Karl, Srivastava, Madhulika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439925/
https://www.ncbi.nlm.nih.gov/pubmed/22718969
http://dx.doi.org/10.1093/nar/gks556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439925/
https://www.ncbi.nlm.nih.gov/pubmed/22718969
http://dx.doi.org/10.1093/nar/gks556

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