BRCA1/2 Mutations Appear Embryo-Lethal Unless Rescued by Low (CGG n<26) FMR1 Sub-Genotypes: Explanation for the “BRCA Paradox”?

BRCA1/2 mutations and recently described constitutional FMR1 genotypes have, independently, been associated with prematurely diminished ovarian reserve. Whether they interrelate in distribution, and whether observed effects of BRCA1/2 and FMR1 on ovaries are independent of each other, is unknown. In...

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Detalles Bibliográficos
Autores principales: Weghofer, Andrea, Tea, Muy-Kheng, Barad, David H., Kim, Ann, Singer, Christian F., Wagner, Klaus, Gleicher, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440327/
https://www.ncbi.nlm.nih.gov/pubmed/22984553
http://dx.doi.org/10.1371/journal.pone.0044753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440327/
https://www.ncbi.nlm.nih.gov/pubmed/22984553
http://dx.doi.org/10.1371/journal.pone.0044753

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