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The Prothrombotic Phenotypes in Familial Protein C Deficiency Are Differentiated by Computational Modeling of Thrombin Generation

The underlying cause of thrombosis in a large protein C (PC) deficient Vermont kindred appears to be multicausal and not explained by PC deficiency alone. We evaluated the contribution of coagulation factors to thrombin generation in this population utilizing a mathematical model that incorporates a...

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Detalles Bibliográficos
Autores principales:	Brummel-Ziedins, Kathleen E., Orfeo, Thomas, Callas, Peter W., Gissel, Matthew, Mann, Kenneth G., Bovill, Edwin G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440432/ https://www.ncbi.nlm.nih.gov/pubmed/22984498 http://dx.doi.org/10.1371/journal.pone.0044378

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