Caspase-Mediated Truncation of Tau Potentiates Aggregation

Caspase-mediated truncation of tau is associated with aggregation. We examined the impact of manipulation of caspase activity on intracellular aggregation of a mutant form of tau (3PO) that forms spontaneous aggregates. Treatment with the caspase inhibitor Z-VAD-fmk reduced both N and C-terminal tau...

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Detalles Bibliográficos
Autores principales: Lee, Sangmook, Shea, Thomas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440879/
https://www.ncbi.nlm.nih.gov/pubmed/22988541
http://dx.doi.org/10.1155/2012/731063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440879/
https://www.ncbi.nlm.nih.gov/pubmed/22988541
http://dx.doi.org/10.1155/2012/731063

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