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Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy

BACKGROUND: Mechanical ventilation with high tidal volumes may cause ventilator-induced lung injury (VILI) and enhanced generation of nitric oxide (NO). We demonstrated in sheep that pneumonectomy followed by injurious ventilation promotes pulmonary edema. We wished both to test the hypothesis that...

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Detalles Bibliográficos
Autores principales: Suborov, Evgeny V, Smetkin, Alexey A, Kondratiev, Timofey V, Valkov, Andrey Y, Kuzkov, Vsevolod V, Kirov, Mikhail Y, Bjertnaes, Lars J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441363/
https://www.ncbi.nlm.nih.gov/pubmed/22720843
http://dx.doi.org/10.1186/1471-2253-12-10