LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

Mutations in the LRRK2 gene are the most common cause of genetic Parkinson’s disease. Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not clear, data emerging from in vitro and in vivo models suggests roles in regulating neuronal polarity, neurotransmission, membra...

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Detalles Bibliográficos
Autores principales: Hinkle, Kelly M, Yue, Mei, Behrouz, Bahareh, Dächsel, Justus C, Lincoln, Sarah J, Bowles, Erin E, Beevers, Joel E, Dugger, Brittany, Winner, Beate, Prots, Iryna, Kent, Caroline B, Nishioka, Kenya, Lin, Wen-Lang, Dickson, Dennis W, Janus, Christopher J, Farrer, Matthew J, Melrose, Heather L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441373/
https://www.ncbi.nlm.nih.gov/pubmed/22647713
http://dx.doi.org/10.1186/1750-1326-7-25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441373/
https://www.ncbi.nlm.nih.gov/pubmed/22647713
http://dx.doi.org/10.1186/1750-1326-7-25

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