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Infrared optical imaging of matrix metalloproteinases (MMPs) up regulation following ischemia reperfusion is ameliorated by hypothermia

BACKGROUND: We investigated the use of a new MMP activatable probe MMPSense(™) 750 FAST (MMPSense750) for in-vivo visualization of early MMP activity in ischemic stroke. Following middle cerebral artery occlusion (MCAO) optical imaging was performed. Near-infrared (NIR) fluorescent images of MMPSens...

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Detalles Bibliográficos
Autores principales: Barber, Philip A, Rushforth, David, Agrawal, Smriti, Tuor, Ursula I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441425/
https://www.ncbi.nlm.nih.gov/pubmed/22742423
http://dx.doi.org/10.1186/1471-2202-13-76