Spontaneous Excitation Patterns Computed for Axons with Injury-like Impairments of Sodium Channels and Na/K Pumps

In injured neurons, “leaky” voltage-gated sodium channels (Nav) underlie dysfunctional excitability that ranges from spontaneous subthreshold oscillations (STO), to ectopic (sometimes paroxysmal) excitation, to depolarizing block. In recombinant systems, mechanical injury to Nav1.6-rich membranes ca...

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Detalles Bibliográficos
Autores principales: Yu, Na, Morris, Catherine E., Joós, Béla, Longtin, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441427/
https://www.ncbi.nlm.nih.gov/pubmed/23028273
http://dx.doi.org/10.1371/journal.pcbi.1002664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441427/
https://www.ncbi.nlm.nih.gov/pubmed/23028273
http://dx.doi.org/10.1371/journal.pcbi.1002664

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