Stochastic Simulations Suggest that HIV-1 Survives Close to Its Error Threshold

The use of mutagenic drugs to drive HIV-1 past its error threshold presents a novel intervention strategy, as suggested by the quasispecies theory, that may be less susceptible to failure via viral mutation-induced emergence of drug resistance than current strategies. The error threshold of HIV-1, [...

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Detalles Bibliográficos
Autores principales: Tripathi, Kushal, Balagam, Rajesh, Vishnoi, Nisheeth K., Dixit, Narendra M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441496/
https://www.ncbi.nlm.nih.gov/pubmed/23028282
http://dx.doi.org/10.1371/journal.pcbi.1002684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441496/
https://www.ncbi.nlm.nih.gov/pubmed/23028282
http://dx.doi.org/10.1371/journal.pcbi.1002684

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