PI3Kγ Drives Priming and Survival of Autoreactive CD4(+) T Cells during Experimental Autoimmune Encephalomyelitis

The class IB phosphoinositide 3-kinase gamma enzyme complex (PI3Kγ) functions in multiple signaling pathways involved in leukocyte activation and migration, making it an attractive target in complex human inflammatory diseases including MS. Here, using pik3cg (−/−) mice and a selective PI3Kγ inhibit...

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Detalles Bibliográficos
Autores principales: Comerford, Iain, Litchfield, Wendel, Kara, Ervin, McColl, Shaun R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441529/
https://www.ncbi.nlm.nih.gov/pubmed/23028778
http://dx.doi.org/10.1371/journal.pone.0045095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441529/
https://www.ncbi.nlm.nih.gov/pubmed/23028778
http://dx.doi.org/10.1371/journal.pone.0045095

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