Stem Cell Selection In Vivo Using Foamy Vectors Cures Canine Pyruvate Kinase Deficiency

BACKGROUND: Hematopoietic stem cell (HSC) gene therapy has cured immunodeficiencies including X-linked severe combined immunodeficiency (SCID-X1) and adenine deaminase deficiency (ADA). For these immunodeficiencies corrected cells have a selective advantage in vivo, and low numbers of gene-modified...

Descripción completa

Detalles Bibliográficos
Autores principales: Trobridge, Grant D., Beard, Brian C., Wu, Robert A., Ironside, Christina, Malik, Punam, Kiem, Hans-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441638/
https://www.ncbi.nlm.nih.gov/pubmed/23028826
http://dx.doi.org/10.1371/journal.pone.0045173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441638/
https://www.ncbi.nlm.nih.gov/pubmed/23028826
http://dx.doi.org/10.1371/journal.pone.0045173

Ejemplares similares