Phosphorylation of Rad9 at Serine 328 by Cyclin A-Cdk2 Triggers Apoptosis via Interfering Bcl-xL

Cyclin A-Cdk2, a cell cycle regulated Ser/Thr kinase, plays important roles in a variety of apoptoticprocesses. However, the mechanism of cyclin A-Cdk2 regulated apoptosis remains unclear. Here, we demonstrated that Rad9, a member of the BH3-only subfamily of Bcl-2 proteins, could be phosphorylated...

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Detalles Bibliográficos
Autores principales: Zhan, Zhuo, He, Kan, Zhu, Dan, Jiang, Dan, Huang, Ying-Hui, Li, Yang, Sun, Chao, Jin, Ying-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441668/
https://www.ncbi.nlm.nih.gov/pubmed/23028682
http://dx.doi.org/10.1371/journal.pone.0044923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441668/
https://www.ncbi.nlm.nih.gov/pubmed/23028682
http://dx.doi.org/10.1371/journal.pone.0044923

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