Sequences Located within the N-Terminus of the PD-Linked LRRK2 Lead to Increased Aggregation and Attenuation of 6-Hydroxydopamine-Induced Cell Death

Clinical symptoms of Parkinson's disease (PD) arise from the loss of substantia nigra neurons resulting in bradykinesia, rigidity, and tremor. Intracellular protein aggregates are a pathological hallmark of PD, but whether aggregates contribute to disease progression or represent a protective m...

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Detalles Bibliográficos
Autores principales: Pandey, Neeraj, Fahey, Mark T., Jong, Yuh-Jiin I., O'Malley, Karen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441673/
https://www.ncbi.nlm.nih.gov/pubmed/23028814
http://dx.doi.org/10.1371/journal.pone.0045149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441673/
https://www.ncbi.nlm.nih.gov/pubmed/23028814
http://dx.doi.org/10.1371/journal.pone.0045149

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