Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age

The creatine kinase (CK) energy transport and buffering system supports cardiac function at times of high demand and is impaired in the failing heart. Mice deficient in muscle- and mitochondrial-CK (M/Mt-CK(−/−)) have previously been described, but exhibit an unexpectedly mild phenotype of compensat...

Descripción completa

Detalles Bibliográficos
Autores principales: Lygate, Craig A., Medway, Debra J., Ostrowski, Philip J., Aksentijevic, Dunja, Sebag-Montefiore, Liam, Hunyor, Imre, Zervou, Sevasti, Schneider, Jurgen E., Neubauer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442167/
https://www.ncbi.nlm.nih.gov/pubmed/22760499
http://dx.doi.org/10.1007/s00395-012-0276-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442167/
https://www.ncbi.nlm.nih.gov/pubmed/22760499
http://dx.doi.org/10.1007/s00395-012-0276-2

Ejemplares similares