DGCR8 HITS-CLIP reveals novel functions for the Microprocessor

The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as the endonuclease. High-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) was used to identify RNA targets of DGCR8 in human cell...

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Detalles Bibliográficos
Autores principales: Macias, Sara, Plass, Mireya, Stajuda, Agata, Michlewski, Gracjan, Eyras, Eduardo, Cáceres, Javier F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442229/
https://www.ncbi.nlm.nih.gov/pubmed/22796965
http://dx.doi.org/10.1038/nsmb.2344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442229/
https://www.ncbi.nlm.nih.gov/pubmed/22796965
http://dx.doi.org/10.1038/nsmb.2344

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